The home confines of Wrigley Field did not provide the comfort needed to give the Cubs the series lead. The Indians shrugged off some questionable base running to take a 2–1 game lead in the 2016 World Series.

The Cleveland Indians looked to jump out in front of the Cubs early when Kipnis reached on an infield single. Lindor followed with his own single moving Kipnis to third. Francisco Lindor took a large lead at first base as Hendricks threw over to keep him honest. Lindor wasn’t expecting it and took a late dive back into the bag. The ump called him safe on the play but the Cubs challenged the called. In a huge momentum swing, the ump reversed the call and Lindor were called out. The Indians left Kipnis stranded at third to end the inning.

Nothing really worked for the Cubs at the plate as the Indians outhit them for most of the game. The Cubs defense and pitching were able to hold as the Indians left the bases loaded in the fifth inning. In the seventh inning, base running drama unfolded again for the Indians.

Martinez reached third for the Indians but a throwback to third from the catcher led to another review from the booth. This time the Indians received good news and Martinez was able to stay at third. This paid off as pinch-hitter Coco Crisp singled into right field and Martinez was able to walk into home. Crisp gave the Indians the 1–0 lead they would take into the bottom of the ninth.

The bottom of the ninth inning for the Cubs started with a single from Rizzo. Contreras was subbed in as a pinch-runner and was able to reach third after a two-out infield single from Jason Heyward. That was the closest the Cubs were able to get to scoring as Contreras was stranded at third when Báez struck out swinging to end the game.